Strong anion exchangers (SAX) have been widely used in both chromatography and ion exchange SPE to selectively bind acidic drugs and/or analytes. In particular, weakly acidic compounds can be effectively extracted as those types of sorbents retain a permanent positive charge across the pH range. Most commercially available silica-based SAX sorbents are produced with a high selectivity chloride counter ion which reduced retention of acidic drugs when compared with lower selectivity counter ions such as acetate. Therefore, users traditionally perform the exchange of the chloride ion prior to sample loading. This process can be time consuming and the exchange may be incomplete.

To this end, SiliCycle has developed SiliaBond^® TMA Acetate (Si-TMAAc), a strong anion exchange sorbent with a low selectivity acetate counter ion already in place. Typical loading is 1.0 mmol/g which is higher than other equivalents available on the market.

This sorbent retains more favorably acidic compounds with pKa < 5, such as carboxylic acid. This property can be used in synthetic chemistry applications to selectively purify acidic compounds or remove acidic impurities from reaction mixtures.

PRODUCT SPECIFICATIONS

MSDS-R66430B

APPLICATION NOTE
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POSTER
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SiliaBond^® C2 nec is a non-polar sorbent and presents a moderate hydrophobicity. This phase is used to extract extremely non-polar compounds.

SiliaBond^® C2 nec is a non-polar sorbent and presents a moderate hydrophobicity. This phase is used to extract extremely non-polar compounds.

SiliaBond^® C4 (or C4) provides less retention towards non-polar compounds than C18 and C8, and is useful in ion-pairing chromatography or to separate large biomolecules.  It works best for molecules with a large hydrophilic region or in case where the hydrophobic region is buried within the structure.

POSTER
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SiliaBond^®  Guanidine is a silica-supported diisopropylguanidine ligand.

It is a very powerful scavenger for the chelating of organic acids in general, especially boronic acids
and phenolic acids.

It may also be used as a very strong base. It is sufficiently basic to deprotonate moderately acidic hydrogens,
as in the alkylation of amines and phenols (Williamson ether synthesis) and the esterification of carboxylic acids using alkyl halides.

It is also a new product that replaces SiliaBond TBD.

SPECIFICATION SHEET

Download the Specification Sheet

APPLICATION NOTE

Application Note for SiliaBond Guanidine