SiliaBond^®  Guanidine is a silica-supported diisopropylguanidine ligand.

It is a very powerful scavenger for the chelating of organic acids in general, especially boronic acids
and phenolic acids.

It may also be used as a very strong base. It is sufficiently basic to deprotonate moderately acidic hydrogens,
as in the alkylation of amines and phenols (Williamson ether synthesis) and the esterification of carboxylic acids using alkyl halides.

It is also a new product that replaces SiliaBond TBD.

SPECIFICATION SHEET

Download the Specification Sheet

APPLICATION NOTE

Application Note for SiliaBond Guanidine

SiliaMetS^® Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts.

Metals Removed

• Best scavenger for: Cd, Co, Cu, Fe, Ir, Li, Mg, Ni, Os, W & Zn
• Good scavenger for: Cr, Pd & Rh

SiliaMetS Imidazole can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.

MSDS-R79230B

APPLICATION NOTE
Click here to see the application notes about SiliaMets^®

POSTERS
Click here to see all the documentation about SiliaMets^®

RELATED PUBLICATION

1. J. Chromato. A, 1142 (2007) 32

SiliaBond^® Carbamate (CAR) is a versatile scavenger for nucleophiles. It readily scavenges amines, thiols, thiolates, alcohols, alkoxides, and acidic phenols. Loading is determined by the removal of benzylamine in hexane at room temperature.

Si-CAR has been used to scavenge amines in a “cap-tag” methodology for oligosaccharide preparation by automated solid phase synthesis¹ and in the preparation of 2,5-diketopiperazines and 1,4-benzodiazepine-2,5-diones.²

Silica supported Carbamate has superior reactivity in a broader range of solvents when compared to polymer-based materials.

RELATED PUBLICATIONS

1. Angew. Chem. Int. Ed., 40 (2001) 4433
2. Org. Lett., 4 (2002) 1167