The World’s Largest Commercial Clone Library

The World’s Largest Commercial  Clone Library

• Over 20 million clones
•  Sequence verification availab
•  Plasmid preparation service
•  Rapid turnaround times

CLONE PORTFOLIO
• cDNA/ORF (IMAGE, MGC, FANTOM
EST, ORF)
• RNAi (Human miRNA, shRNAm,
MISSION siRNA, C. elegans RNAi)
• Antibody libraries (Human Single
fold scFv libraries I + J, Human Domain
antibody library (DAb), ATLAS ScFV)
• Synthetic genes (made to order)

Genomic
•     Human (CpG island, TilePath BAC,
minimal genomic clone set, BAC
(RPCI-11)
•     C.elegans (promoterome library,
fosmid library)
•     Chicken (BAC, CpG island)
•     Drosophilia cosmid
•     Fugu (BAC, cosmid)
•     Mouse (bMQ BAC, BAC (RPCI-23),
PAC, Cosmid (strain 129/ola)
•     Zebrafish BAC
•     Pig CpG Island

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Intuitive and fast
search of the largest
publically available
database of over 20
million clones and
150,000 antibodies

Find out more:
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Human Domain Antibody Library (DAb library)

Human Domain Antibody Library源自MRC Daniel Christ实验室, Human Domain Antibody Library明显优于Tomlinson I + J 文库,可以通过噬菌体展示技术产生针对任何目的抗原的抗体。该类抗体可用于ELISA, Western blotting, FACS, IHC等免疫学试验。该噬菌体文库已经在很多分子生物学实验室成功使用,可在大量不同的蛋白,多肽,小分子复合物中诱导出特异性抗体反应物。

噬菌体展示技术利用基因克隆技术将B细胞全套可变区基因克隆出来,组装到表达载体内并表达到噬菌体表面,并通过“吸附-洗脱-扩增”的富集过程,从中筛选特异性抗体的可变区基因。Human Domain Antibody构建在pR2(MYC VSV  标签)上,多元化的侧链在 CDR1、CDR2 和 CDR 3:H27 33、H35、H50、H52 H54、H94、H95-H100(a-k)、H101、H102。经过筛选后与突变的多样性体细胞共同作用使其成熟。该文库基于VH框架(V3-23/D47),抗原结合区域的多样性的引入通过PCR突变CDR1、CDR2和CDR3。此文库有以下优点:

· 产生结合剂到模型折叠抗原上,无冷却后抗原结合活性的重大损失。

· 抗体选择后,通过25次热变形循环,竞争抗耐性的嗜热蛋白如Taq酶,保持抗原结合活性。

· 在噬菌体中,所有组分可经受热诱导聚集反应。

以上提到的优点,可为诊断和治疗的研究与应用提供广泛领域,可以进一步实现较大化结合你感兴趣的抗原数量。

文库以下面形式提供:

· Phagemid antibody library (~3×10 9 )

· Helper phage KM13

· Host strain TG1Tr

· Optimised antibody expression strain HB2151

· Controls: anti-beta-galactosidase & anti-bovine ubiquitin antibodies

· Detailed protocol

Source Bioscience (Geneservice)与全球多个科研机构(如NIH、NKI、Sanger等)建立合作关系,拥有全球较大的cDNA、基因组、噬菌体展示、microRNA、siRNA、shRNA与MGC收藏库,涉及物种包括人、小鼠、大鼠、牛,以及各种模式动物如线虫、斑马鱼、果蝇、原鸡、爪蟾等,产品达1600多万种。Human Domain Antibody Library是Source Bioscience提供的较为成熟的一个文库,除此之外,还有Tomlinson I + J 文库,以及ATLAS scFV library。

更多产品可点击 Source Bioscience查询具体信息。

上海金畔生物科技有限公司成为美国Source Bioscience中国地区一级代理,双方携手为国内科研工作者提供物种齐全的克隆及文库,欢迎您来电咨询和申请。

Interferon γ/ IFN-γ/ IFNG, Human, Recombinant


Interferon γ/ IFN-γ/ IFNG, Human, Recombinant

货号:PCK063

价格:¥780¥1880¥7880¥9980

规格:

10µg

  • 10µg
  • 50µg
  • 500µg
  • 1mg

  • 产品概述
  • 相关产品推荐

产品概述

产品信息

别名 Interferon Gamma; IFN-Gamma; Immune Interferon; IFNG
物种 Human
表达宿主 Human Cells
序列信息 asd
检索号 P01579
分子量 16.8 kDa
表观分子量 16&20-25 kDa
生物活性 Measured by a viral resistance assay using VSV-WISH cells.Specific Activity is greater than 1.5?0^7 IU/ mg.

产品特性

纯度 >90% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.0.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

IFNγ is the major interferon produced by mitogenically or antigenically stimulated lymphocytes. It is structurally different from type I interferon and its major activity is immunoregulation. It has been implicated in the expression of class II histocompatibility antigens in cells that do not normally produce them, leading to autoimmune disease. Interferon gamma is produced mainly byT-cells and natural killer cells activated by antigens, mitogens, or alloantigens. It is produced by lymphocytes expressing the surface antigens CD4 and CD8. IFNγ synthesis is induced by IL-2, FGF-basic, and EGF.
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IL-12/ IL12A, Human, Recombinant


IL-12/ IL12A, Human, Recombinant

货号:PCK171

价格:¥1780¥4980¥17480¥27980

规格:

10µg

  • 10µg
  • 50µg
  • 500µg
  • 1mg

  • 产品概述
  • 相关产品推荐

产品概述

产品信息

别名 Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; NK cell; IL12A ; NKSF1 stimulatory factor chain 1;
物种 Human
表达宿主 Human Cells
序列信息 asd
检索号 NP_002178.2
分子量 22.5&34.7 kDa
表观分子量 40-50 kDa
生物活性 Testing in progress

产品特性

纯度 >90% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

IL-12 is a heterodimeric pleiotropic Cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit.Human and mouse IL-12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-γ. T cells that produce IL-12 have a coReceptor, CD30, which is associated with IL-12 activity.IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes.
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IL-13RA1/ IL13RA, Human, Recombinant


IL-13RA1/ IL13RA, Human, Recombinant

货号:PCK173

价格:¥780¥1380¥6880¥11180

规格:

10µg

  • 10µg
  • 50µg
  • 500µg
  • 1mg

  • 产品概述
  • 相关产品推荐

产品概述

产品信息

别名 Interleukin-13 Receptor subunit alpha-1; IL-13 Receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; Cancer/ testis antigen 19; CT19; CD213a1; IL13RA1; IL13R; IL13RA
物种 Human
表达宿主 Human Cells
序列信息 asd
检索号 P78552
分子量 37.7 kDa
表观分子量 55-65 kDa
标签 C-6His
生物活性 Measured by its ability to inhibit IL-13-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 2.1 ug/ml.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Interleukin-13 Receptor subunit alpha-1 (IL13RA1) is a subunit of the Interleukin 13 Receptor. This subunit forms a Receptor complex with IL4 Receptor alpha, a subunit shared by IL13 and IL4 Receptors. The human IL13-Rα1 was originally cloned based on sequence homology to the mouse IL13-Rα1, it share 76% aa sequence identity. Human The IL13-Rα1 cDNA encodes a 427 amino acid (aa) residue precursor Protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. The extracellular domain of IL13-Rα1 is also closely related to that of IL13-Rα2. It binds with low affinity to Interleukin-13 (IL13). IL13RA1 serves as a primary IL13- binding subunit of the IL13 Receptor, and may also be a component of IL4 Receptors. This Protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
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IL-16/ LCF, Human, Recombinant


IL-16/ LCF, Human, Recombinant

货号:PCK175

价格:¥1780¥4980¥20880¥30880

规格:

10µg

  • 10µg
  • 50µg
  • 500µg
  • 1mg

  • 产品概述
  • 相关产品推荐

产品概述

产品信息

别名 Pro-Interleukin-16; Interleukin-16; IL-16; Lymphocyte Chemoattractant Factor; LCF; IL16
物种 Human
表达宿主 E.coli
序列信息 asd
检索号 AAC12732.1
分子量 13.4 kDa
表观分子量 18 kDa
生物活性 Measured by its to chemoattract human CD4+ T-lymphocytes using a concentration range of 10.0-100.0 ng/ mlThe ED50 for this effect is typically 0.1 ug/ mL.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.0.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Interleukin-16 (IL-16) is a CD8+ T cell-Derived Cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that Receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 Receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity.
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IL-17A/ F (C-6His), Human, Recombinant


IL-17A/ F (C-6His), Human, Recombinant

货号:PCK176

价格:¥1780¥4980¥17480¥27980

规格:

10µg

  • 10µg
  • 50µg
  • 500µg
  • 1mg

  • 产品概述
  • 相关产品推荐

产品概述

产品信息

别名 IL-17A/ F Heterodimer; IL-17A&IL-17F Heterodimer
物种 Human
表达宿主 Human Cells
序列信息 asd
检索号 Q16552&Q96PD4
分子量 43.2 kDa
表观分子量 15-18 kDa
标签 C-6His
生物活性 Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells.The ED50 for this effect is typically 0.2 ng/ mL.

产品特性

纯度 >90% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

The IL-17 family include IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. The family is comprised of at least six proinflammatory Cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. All members of the IL-17 family have a similar Protein structure, with four highly conserved cysteine residues critical to their 3-dimensional shape, yet they have no sequence similarity to any other known Cytokines. IL-17 family members are glyco Proteins secreted as dimers that induce local Cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes.
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IL-17A/ CTLA8 (C-6His), Human, Recombinant


IL-17A/ CTLA8 (C-6His), Human, Recombinant

货号:PCK178

价格:¥1280¥2980¥17480¥25680

规格:

10µg

  • 10µg
  • 50µg
  • 500µg
  • 1mg

  • 产品概述
  • 相关产品推荐

产品概述

产品信息

别名 Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17
物种 Human
表达宿主 Human Cells
序列信息 asd
检索号 Q16552
分子量 20.5 kDa
表观分子量 19 kDa
标签 C-6His
生物活性 Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells.The ED50 for this effect is less than 500 ng/ ml.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Interleukin-17 is a potent pro-inflammatory Cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This Cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of Interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
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IL-18/ IL-1F4 (C-6His), Human, Recombinant


IL-18/ IL-1F4 (C-6His), Human, Recombinant

货号:PCK180

价格:¥1380¥3680¥17480¥25680

规格:

10µg

  • 10µg
  • 50µg
  • 500µg
  • 1mg

  • 产品概述
  • 相关产品推荐

产品概述

产品信息

别名 Interleukin-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; GIF; IL-18; IL-1g; IL1F4; MGC12320
物种 Human
表达宿主 Human Cells
序列信息 asd
检索号 Q14116
分子量 23.3 kDa
表观分子量 23 kDa
标签 C-6His
生物活性 Measured by its ability to induce NFKB reporter gene expression in HEK 293 cell line.The ED50 for this effect is typically 25.3ng/ mL.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Interleukin-18 is a secreted Protein and it belongs to the IL-1 family. IL-18 is a proinflammatory Cytokine and produced by macrophages and other cells. This Cytokine can induce the IFN-gamma production of T cells. The combination of this Cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding Protein (IL18BP) can specifically interact with this Cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important Cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.
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IL-18BP (C-Fc), Human, Recombinant


IL-18BP (C-Fc), Human, Recombinant

货号:PCK181

价格:¥680¥1380¥7880¥9980

规格:

10µg

  • 10µg
  • 50µg
  • 500µg
  • 1mg

  • 产品概述
  • 相关产品推荐

产品概述

产品信息

别名 Interleukin-18-binding Protein; Tadekinig-alfa and IL18BP;
物种 Human
表达宿主 Human Cells
序列信息 asd
检索号 O95998
分子量 44.7 kDa
表观分子量 55 kDa
标签 C-Fc
生物活性 Testing in progress

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Interleukin-18-binding Protein, also known as Tadekinig-alfa and IL18BP, contains 1 Ig-like C2-type domain. IL18BP is constitutively expressed and secreted in mononuclear cells. IL18BP functions as an IL18 inhibitor. IL18BP binds to IL18, prevents the binding of IL18 to its Receptor, and thus inhibits IL18-induced IFN-gamma production. It has been shown that IL18BP may be a promising molecular approach to inhibit neointimal hyperplasia and arteriosclerosis progression following coronary and peripheral angioplasty.
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