HGF R/ c-Met/ HGFR, Human, Recombinant

HGF R/ c-Met/ HGFR, Human, Recombinant





  • 10µg
  • 50µg
  • 500µg
  • 1mg

  • 产品概述
  • 相关产品推荐



别名 Hepatocyte Growth Factor Receptor; HGF Receptor; HGF/ SF Receptor; Proto-oncogene c-Met; Scatter factor Receptor; SF Receptor; Tyrosine- Protein kinase Met; MET
物种 Human
表达宿主 Human Cells
序列信息 asd
检索号 P08581
分子量 102.5 kDa
表观分子量 80-94&130 kDa
标签 C-6His
生物活性 Testing in progress


纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


Hepatocyte Growth Factor Receptor (HGF R) is a glycosylated Receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domain, consist of secreted extracellular domains, or are deficient in proteolytic separation of the α and β chains. The sema domain, which is formed by both α and β chains of HGF R, mediates both Ligand binding and Receptor dimerization. HGF stimulation induces HGF R downregulation via internalization and proteasomedependent degradation. Paracrine induction of epithelial cell scattering and branching tubulogenesis results from the stimulation of HGF R on undifferentiated epithelium by HGF released from neighboring mesenchymal cells.
  • IL-4Rα/ CD124 (C-mFc), Human, Recombinant
  • FGF-8/ AIGF (N-6His), Human, Recombinant
  • GRO-γ/ CXCL3 (N-6His), Human, Recombinant