IL-18/ IL-1F4, Human, Recombinant

IL-18/ IL-1F4, Human, Recombinant





  • 10µg
  • 50µg
  • 500µg
  • 1mg

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别名 Interleukin-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; GIF; IL-18; IL-1g; IL1F4; MGC12320
物种 Human
表达宿主 E.coli
序列信息 asd
检索号 Q14116
分子量 18.2 kDa
表观分子量 17 kDa
生物活性 Measured by its ability to induce NFKB reporter gene expression in HEK 293 cell line.The ED50 for this effect is less than 25ng/ mL.


纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


Interleukin-18 is a secreted Protein and it belongs to the IL-1 family. IL-18 is a proinflammatory Cytokine and produced by macrophages and other cells. This Cytokine can induce the IFN-gamma production of T cells. The combination of this Cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding Protein (IL18BP) can specifically interact with this Cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important Cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.
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