IL-12/ IL12A, Human, Recombinant
货号：PCK171
价格：¥1780¥4980¥17480¥27980
规格：
10µg
- 10µg
- 50µg
- 500µg
- 1mg
- 产品概述
- 相关产品推荐
产品概述
产品信息
| 别名 | Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; NK cell; IL12A ; NKSF1 stimulatory factor chain 1; |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | asd |
| 检索号 | NP_002178.2 |
| 分子量 | 22.5&34.7 kDa |
| 表观分子量 | 40-50 kDa |
| 生物活性 | Testing in progress |
产品特性
| 纯度 | >90% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
IL-12 is a heterodimeric pleiotropic Cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit.Human and mouse IL-12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-γ. T cells that produce IL-12 have a coReceptor, CD30, which is associated with IL-12 activity.IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes.
相关产品推荐
- IP-10/ CRG-2/ CXCL10 (C-Fc-6His), Human, Recombinant
- TNF-R2/ CD120b/ TNFRSF1B (C-mFc), Human, Recombinant
- IL-10RB (C-Fc), Human, Recombinant