IL-17A/ CTLA8, Human, Recombinant
货号:PCK177
价格:¥780¥1880¥13880¥19980
规格:
10µg
- 10µg
- 50µg
- 500µg
- 1mg
- 产品概述
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产品概述
产品信息
别名 | Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17 |
物种 | Human |
表达宿主 | E.coli |
序列信息 | asd |
检索号 | Q16552 |
分子量 | 15.26 kDa |
表观分子量 | 16 kDa |
生物活性 | Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells.The ED50 for this effect is 1-7 ng/ml. |
产品特性
纯度 | >95% as determined by reducing SDS-PAGE. |
内毒素 | < 1.0 EU per µg as determined by LAL test. |
保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, pH 7.4. |
复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Interleukin-17 is a potent pro-inflammatory Cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This Cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of Interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
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