IL-22, Human, Recombinant
货号:PCK183
价格:¥1780¥4980¥17480¥27980
规格:
10µg
- 10µg
- 50µg
- 500µg
- 1mg
- 产品概述
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产品概述
产品信息
别名 | Interleukin-22; IL-22; Cytokine Zcyto18; IL-10-related T-cell-Derived-inducible factor; IL-TIF; IL22; ILTIF; ZCYTO18 |
物种 | Human |
表达宿主 | E.coli |
序列信息 | asd |
检索号 | Q9GZX6 |
分子量 | 16.9 kDa |
表观分子量 | 14 kDa |
生物活性 | Measured by its ability to induce IL-10 secretion in COLO?05 human colorectal adenocarcinoma cells.The ED50 for this effect is less than 1 ng/ ml. |
产品特性
纯度 | >95% as determined by reducing SDS-PAGE. |
内毒素 | < 1.0 EU per µg as determined by LAL test. |
保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Interleukin-22 (IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 Receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 Receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding Protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by Cytokine IL-17A.
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