IL-22, Human, Recombinant


IL-22, Human, Recombinant

货号:PCK183

价格:¥1780¥4980¥17480¥27980

规格:

10µg

  • 10µg
  • 50µg
  • 500µg
  • 1mg

  • 产品概述
  • 相关产品推荐

产品概述

产品信息

别名 Interleukin-22; IL-22; Cytokine Zcyto18; IL-10-related T-cell-Derived-inducible factor; IL-TIF; IL22; ILTIF; ZCYTO18
物种 Human
表达宿主 E.coli
序列信息 asd
检索号 Q9GZX6
分子量 16.9 kDa
表观分子量 14 kDa
生物活性 Measured by its ability to induce IL-10 secretion in COLO?05 human colorectal adenocarcinoma cells.The ED50 for this effect is less than 1 ng/ ml.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Interleukin-22 (IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 Receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 Receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding Protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by Cytokine IL-17A.
相关产品推荐
  • TNF-β/ TNFB/ TNFSF1, Human, Recombinant
  • IL-2RB/ CD122 (C-6His), Human, Recombinant
  • FGF-2/ bFGF/ FGF-b (Pro143-Ser288), Human, Recombinant