IGF-I/ IGF1/ MGF, Human, Recombinant

IGF-I/ IGF1/ MGF, Human, Recombinant

货号:PCK017

价格:¥500¥1180¥1880¥2580

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg

  • 产品概述
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产品概述

产品信息

别名 Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1
物种 Human
表达宿主 E.coli
序列信息 Gly49-Ala118
检索号 P05019
分子量 7.6 kDa
表观分子量 9 kDa
生物活性 Measured by its ability to induce NFKB reporter gene expression in HEK 293 cell line. Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cellsThe ED50 for this effect is less than 200 ng/ ml.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 300mM NaAc, pH 6.5.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in 50mM Acetic Acid. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Insulin-Like Growth Factor I (IGF1) belongs to the family of Insulin-Like Growth Factors that are structurally homologous to proInsulin. Mature IGFs are generated by proteolytic processing of inactive precursor Proteins, which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR, IGF-IIR, and the Insulin Receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF-1 expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu (E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.
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